Trent Tipple, MD

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Trent Tipple, MD

Research Project:
Determing Selenium’s Role in Bronchopulmonary Dysplasia

Grant Awarded:

Innovation Award

Research Topic:

basic biologic mechanisms

Research Disease:

bronchopulmonary dysplasia

Bronchopulmonary Dysplasia (BPD) is the leading cause of lung problems in premature babies. BPD is caused by exposure to high oxygen levels (hyperoxia) and poor antioxidant defenses. Selenium is a nutritional element that is needed for antioxidant defense. Selenium deficiency is common in premature babies and is a risk factor for BPD development. Infants who develop BPD have a high risk of life-long lung problems. We will study selenium in a mouse model of BPD. These studies will lead to better understanding of the ways in which selenium contributes to lung development, antioxidant responses, and BPD. By defining the role of selenium, we can better develop therapies to prevent BPD development in premature babies.

Page last updated: April 20, 2024

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